SC 57461

CAS No. 423169-68-0

SC 57461 ( SC 57461A )

Catalog No. M14440 CAS No. 423169-68-0

A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 87 Get Quote
10MG 140 Get Quote
25MG 282 Get Quote
50MG 444 Get Quote
100MG 651 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SC 57461
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
  • Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM), no effect on production of the cyclooxygenase metabolite thromboxane B(2); orally active in vivo.Irritable Bowel Syndrome Discontinued
  • Synonyms
    SC 57461A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    423169-68-0
  • Formula Weight
    363.88
  • Molecular Formula
    C20H25NO3.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1
  • Chemical Name
    3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82.
2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.
3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.
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